ABSTRACT
No abstract available.
Subject(s)
Adult , Humans , Male , Antimetabolites, Antineoplastic/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Bone Marrow Examination , Chemotherapy, Adjuvant , Colectomy , Colorectal Neoplasms/drug therapy , Cytogenetic Analysis , Fluorouracil/adverse effects , Leukemia, Myeloid, Acute/chemically induced , Treatment OutcomeABSTRACT
OBJECTIVE: Inflammatory cytokines may play important roles in the pathogenesis of adult onset Still's disease. The enhanced expression of IL-18 was reported in the bone marrow of a Japanese systemic onset juvenile rheumatoid arthritis patient but not in the other organs. To date, there are very few studies relating the bone marrow and AOSD. This study examined the bone marrow findings as well as TNF-alpha and IL-18 expression in the bone marrow of AOSD patients. METHODS: A retrospective study was performed on 15 AOSD patients who had undergone a bone marrow examination at a university hospital. The clinical and laboratory findings, as well as the bone marrow findings, were analyzed. Immunohistochemistry of IL-18 and TNF-alpha in bone marrow was performed. RESULTS: The bone marrow cellularity and myeloid/erythroid cell ratio showed no correlation with the clinical and laboratory findings. TNF-alpha was expressed at 0.8~9.8% and IL-18 was expressed at 0.4~9.8% of bone marrow cells. Cytokine expression was not associated with the clinical patterns of AOSD. The platelet count correlated with the bone marrow TNF-alpha expression but TNF-alpha did not correlate with IL-18 expression. CONCLUSION: TNF-alpha and IL-18 expression in bone marrow were observed in some AOSD patients but there was no correlation with the other clinical and laboratory findings except for the platelet count.
Subject(s)
Adult , Humans , Arthritis, Juvenile , Asian People , Bone Marrow , Bone Marrow Cells , Bone Marrow Examination , Cytokines , Immunohistochemistry , Interleukin-18 , Platelet Count , Retrospective Studies , Still's Disease, Adult-Onset , Tumor Necrosis Factor-alphaABSTRACT
Klebsiella pneumoniae causes pyogenic infections in various sites, with the risk of which increases in patients with diabetes mellitus. Recently, K. pneumoniae has emerged as a leading cause of pyogenic liver abscess. Primary liver abscess caused by K. pneumoniae in the absence of underlying hepatobiliary disease is commonly associated with metastatic infections such as endophthalmitis, meningitis, brain abscess and infection in other sites. We experienced a case of K. pneumoniae liver abscess associated with septic metastatic lesions including pyomyositis and infected aneurysm of aorta. Despite the aggressive management with antibiotics, surgical pus drainage and aortic bypass graft, patient died of ventilator associated pneumonia and multiorgan failure. Our experience suggests that clinicians should be alert to septic metastatic infections when they treat a patient with K. pneumoniae liver abscess.
Subject(s)
Humans , Aneurysm, Infected , Anti-Bacterial Agents , Aorta , Aortic Aneurysm , Brain Abscess , Diabetes Mellitus , Drainage , Endophthalmitis , Klebsiella , Klebsiella pneumoniae , Liver , Liver Abscess , Liver Abscess, Pyogenic , Meningitis , Pneumonia , Pneumonia, Ventilator-Associated , Pyomyositis , Suppuration , TransplantsABSTRACT
Klebsiella pneumoniae causes pyogenic infections in various sites, with the risk of which increases in patients with diabetes mellitus. Recently, K. pneumoniae has emerged as a leading cause of pyogenic liver abscess. Primary liver abscess caused by K. pneumoniae in the absence of underlying hepatobiliary disease is commonly associated with metastatic infections such as endophthalmitis, meningitis, brain abscess and infection in other sites. We experienced a case of K. pneumoniae liver abscess associated with septic metastatic lesions including pyomyositis and infected aneurysm of aorta. Despite the aggressive management with antibiotics, surgical pus drainage and aortic bypass graft, patient died of ventilator associated pneumonia and multiorgan failure. Our experience suggests that clinicians should be alert to septic metastatic infections when they treat a patient with K. pneumoniae liver abscess.
Subject(s)
Humans , Aneurysm, Infected , Anti-Bacterial Agents , Aorta , Aortic Aneurysm , Brain Abscess , Diabetes Mellitus , Drainage , Endophthalmitis , Klebsiella , Klebsiella pneumoniae , Liver , Liver Abscess , Liver Abscess, Pyogenic , Meningitis , Pneumonia , Pneumonia, Ventilator-Associated , Pyomyositis , Suppuration , TransplantsABSTRACT
Leflunomide is a new disease-modifying drug licensed for treatment of rheumatoid arthritis. Recently, neuropathy has been reported with leflunomide. We report a case of peripheral neuropathy in rheumatoid arthritis treated with leflunomide. Nerve conduction study and electromyogram show sensory-motor polyneuropathy of both upper and lower limbs. Leflunomide medication was discontinued and cholestryamine washout was performed with some improvement in a couple of weeks.
ABSTRACT
Systemic lupus erythematosus (SLE) and ulcerative colitis (UC) are both considered as systemic diseases with an abnormal immune response that depends on interactions between susceptibility genes and environmental factors. Patients with UC may share common manifestations with SLE, for example peripheral arthritis, oral ulcer. Although many autoimmune disorders tend to coexist in one patient, these two diseases are rarely associated with each other. We reported a case of a 36-year-old female where rectal bleeding was identified as ulcerative colitis. She was diagnosed as SLE prior to ulcerative colitis. There are no documented reports on SLE with ulcerative colitis in Korea.